Opportunity Information: Apply for RFA CE 22 011
The grant opportunity titled Understanding Polydrug Use Risk and Protective Factors, Patterns, and Trajectories to Prevent Drug Overdose (RFA CE 22 011) is a CDC National Center for Injury Prevention and Control (NCIPC) call for investigator-initiated research focused on polydrug use and how it contributes to overdose risk. The central purpose is to generate practical, prevention-relevant evidence about why polydrug use happens, how it changes over time, and which circumstances or characteristics increase or decrease the likelihood of nonfatal overdose or overdose death. The emphasis is on producing knowledge that can be translated into more targeted and effective drug use and overdose prevention strategies.
A major focus of the opportunity is on polydrug combinations most strongly associated with overdose, particularly combinations involving synthetic opioids (for example, illicitly manufactured fentanyl and related compounds). CDC highlights several priority categories: using multiple opioids at the same time, whether intentionally or unintentionally (such as when a person does not know a substance is adulterated); combining opioids with non-opioid drugs that are frequently implicated in overdose risk, especially psychostimulants like methamphetamine, cocaine, and benzodiazepines; and other drug combinations that can plausibly elevate overdose risk. The repeated mention of knowingly or unknowingly underscores real-world conditions where drug content and potency may be uncertain, which is a critical driver of overdose risk in many communities.
Applicants are expected to study three connected elements rather than just one: risk and protective factors, patterns of use, and trajectories over time. In practice, that means research should go beyond identifying correlates and should also describe how polydrug use presents (patterns such as which substances are combined, how frequently, in what contexts, and by which routes of administration) and how those patterns evolve (trajectories such as initiation into polydrug use, escalation, periods of abstinence or relapse, and transitions between drug combinations). Protective factors are explicitly included, signaling interest not only in what increases risk but also what reduces it, such as social supports, access to treatment, harm reduction services, clinical practices, policy environments, or other individual and community-level conditions that may buffer overdose risk.
The opportunity allows applicants to focus either on the general population or on specific subpopulations that CDC names as particularly relevant. The listed subpopulations include (1) people who have experienced acute or chronic pain and used prescription opioids for pain management, and (2) people who use cannabis, whether medically or non-medically. Applicants can also propose an alternate subpopulation if they can justify it using prior research or preliminary data, especially if the group has been disproportionately affected by overdose. This flexibility is important because overdose burden and polydrug trends vary across regions and populations, and CDC is leaving room for well-supported proposals that address emerging or locally severe risks.
From an administrative standpoint, this is a discretionary grant in the health funding activity category under CFDA 93.136. Eligibility is broad and includes state, county, and city or township governments; special district governments; independent school districts; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public and Indian housing authorities; nonprofit organizations with and without 501(c)(3) status; for-profit organizations (including small businesses); and other applicants as permitted under the notice. The wide eligibility pool suggests CDC is open to proposals from academic researchers, public agencies, community-based groups, and private-sector research entities, as long as the proposed work aligns with the scientific and public health goals of the announcement.
Key timeline and funding details included in the notice are that the opportunity was created December 8, 2021, with an original application closing date of February 24, 2022, and electronic submissions due by 5:00 pm ET on the due date. The award ceiling is $350,000, and CDC anticipated making about five awards. Overall, the grant is structured to support a small set of focused research projects that can clarify which polydrug combinations and use pathways are most dangerous, identify modifiable risk and protective factors, and ultimately strengthen the evidence base for targeted overdose prevention efforts.Apply for RFA CE 22 011
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Understanding Polydrug Use Risk and Protective Factors, Patterns, and Trajectories to Prevent Drug Overdose" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.136.
- This funding opportunity was created on Dec 08, 2021.
- Applicants must submit their applications by Feb 24, 2022 Electronically submitted applications must be submitted no later than 500 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $350,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification), Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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